Treatment of murine breast cancer cells with antisense RNA to the type I insulin-like growth factor receptor decreases the level of plasminogen activator transcripts, inhibits cell growth in vitro, and reduces tumorigenesis in vivo

Aims: To establish that cells from the murine mammary carcinoma cell line, EMT6, express type I insulin-like growth factor receptor (IGF-IR), tissue-type plasminogen activator (tPA), and urokinase-type plasminogen activator (uPA). To investigate the role of IGF-IR in growth, transformation, and tumo...

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Main Authors: Chernicky, C L, Tan, H, Yi, L, Loret de Mola, J R, Ilan, J
Formato: Artigo
Idioma:Inglês
Publicado em: British Medical Journal Publishing Group 2002
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1187158/
https://ncbi.nlm.nih.gov/pubmed/11950959
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