Flexibility in substrate recognition by thimet oligopeptidase as revealed by denaturation studies

Thimet oligopeptidase (TOP) is a soluble metalloendopeptidase belonging to a family of enzymes including neurolysin and neprilysin that utilize the HEXXH metal-binding motif. TOP is widely distributed among cell types and is able to cleave a number of structurally unrelated peptides. A recent focus...

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Bibliografiska uppgifter
Huvudupphovsmän: Sigman, Jeffrey A., Patwa, Tasneem H., Tablante, Ana V., Joseph, Calleen D., Glucksman, Marc J., Wolfson, Adele J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Portland Press Ltd. 2005
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1186714/
https://ncbi.nlm.nih.gov/pubmed/15647004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20041481
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