Hydrogen bond residue positioning in the 599-611 loop of thimet oligopeptidase is required for substrate selection

Thimet oligopeptidase (EC 3.4.24.15; TOP) is a Zn(II) endopeptidase implicated in the processing of numerous physiological peptides. Though its role in selecting and processing peptides is not fully understood, it is believed that flexible loop regions lining the substrate-binding site allow the enz...

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Bibliographic Details
Main Authors: Bruce, Lisa A., Sigman, Jeffrey A., Randall, Danica, Rodriguez, Scott, Song, Michelle M., Dai, Yi, Elmore, Donald E., Pabon, Amanda, Glucksman, Marc J., Wolfson, Adele J.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2649724/
https://ncbi.nlm.nih.gov/pubmed/18959747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2008.06685.x
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