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An aspartic acid residue at the active site of pepsin. The isolation and sequence of the heptapeptide

Pepsin reacts stoicheiometrically with the active-site-directed irreversible inhibitor N-diazoacetyl-l-phenylalanine methyl ester, with concomitant loss of all proteolytic and peptidolytic activity. The reagent esterifies a unique aspartic acid residue in pepsin, which is in the sequence:Ile-Val-Asp...

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Autors principals: Bayliss, R. S., Knowles, J. R., Wybrandt, Grith B.
Format: Artigo
Idioma:Inglês
Publicat: 1969
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1184645/
https://ncbi.nlm.nih.gov/pubmed/4897201
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