Mechanisms of sodium/calcium selectivity in sodium channels probed by cysteine mutagenesis and sulfhydryl modification.

A conserved lysine residue in the "P loop" of domain III renders sodium channels highly selective. Conversion of this residue to glutamate, to mimic the homologous position in calcium channels, enables Ca2+ to permeate sodium channels. Because the lysine-to-glutamate mutation converts a po...

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Hlavní autoři: Pérez-García, M T, Chiamvimonvat, N, Ranjan, R, Balser, J R, Tomaselli, G F, Marban, E
Médium: Artigo
Jazyk:Inglês
Vydáno: 1997
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1184487/
https://ncbi.nlm.nih.gov/pubmed/9138597
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