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Circuit topology and the evolution of robustness in two-gene circadian oscillators

Many parameters driving the behavior of biochemical circuits vary extensively and are thus not fine-tuned. Therefore, the topology of such circuits (the who-interacts-with-whom) is key to understanding their central properties. I here explore several hundred different topologies of a simple biochemi...

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Autor principal: Wagner, Andreas
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2005
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1183445/
https://ncbi.nlm.nih.gov/pubmed/16087882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0501094102
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