Mutagenesis-Induced, Large Fitness Variations with an Invariant Arenavirus Consensus Genomic Nucleotide Sequence

Enhanced mutagenesis may result in RNA virus extinction, but the molecular events underlying this process are not well understood. Here we show that 5-fluorouracil (FU)-induced mutagenesis of the arenavirus lymphocytic choriomeningitis virus (LCMV) resulted in preextinction populations whose consens...

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Detalhes bibliográficos
Main Authors: Grande-Pérez, Ana, Gómez-Mariano, Gema, Lowenstein, Pedro R., Domingo, Esteban
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Genetic Diversity and Evolution
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1182645/
https://ncbi.nlm.nih.gov/pubmed/16051837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.16.10451-10459.2005
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