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Synergistic recognition of an epigenetic DNA element by Pleiohomeotic and a Polycomb core complex
Polycomb response elements (PREs) are cis-acting DNA elements that mediate epigenetic gene silencing by Polycomb group (PcG) proteins. Here, we report that Pleiohomeotic (PHO) and a multiprotein Polycomb core complex (PCC) bind highly cooperatively to PREs. We identified a conserved sequence motif,...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cold Spring Harbor Laboratory Press
2005
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1182336/ https://ncbi.nlm.nih.gov/pubmed/16077005 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.347005 |
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