Synergistic recognition of an epigenetic DNA element by Pleiohomeotic and a Polycomb core complex

Polycomb response elements (PREs) are cis-acting DNA elements that mediate epigenetic gene silencing by Polycomb group (PcG) proteins. Here, we report that Pleiohomeotic (PHO) and a multiprotein Polycomb core complex (PCC) bind highly cooperatively to PREs. We identified a conserved sequence motif,...

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Main Authors: Mohd-Sarip, Adone, Cléard, Fabienne, Mishra, Rakesh K., Karch, François, Verrijzer, C. Peter
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2005
Teme:
Research Communications
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1182336/
https://ncbi.nlm.nih.gov/pubmed/16077005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.347005
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