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DYRK1A Enhances the Mitogen-activated Protein Kinase Cascade in PC12 Cells by Forming a Complex with Ras, B-Raf, and MEK1

Dual-specificity tyrosine-phosphorylated and regulated kinase 1A (Dyrk1A) is the human homologue of the Drosophila mnb (minibrain) gene. In Drosophila, mnb is involved in postembryonic neurogenesis. In human, DYRK1A maps within the Down syndrome critical region of chromosome 21 and is overexpressed...

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Bibliografiske detaljer
Main Authors: Kelly, Paul A., Rahmani, Zohra
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Cell Biology 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1182298/
https://ncbi.nlm.nih.gov/pubmed/15917294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E04-12-1085
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