Inhibition of the Transforming Growth Factor β (TGFβ) Pathway by Interleukin-1β Is Mediated through TGFβ-activated Kinase 1 Phosphorylation of SMAD3

Transforming growth factor β is the prototype of a large family of secreted factors that regulate multiple biological processes. In the immune system, TGFβ acts as an anti-inflammatory and immunosuppressive molecule, whereas the cytokine interleukin (IL)-1β is a crucial mediator of inflammatory resp...

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Autori principali: Benus, Germaine F.J.D., Wierenga, Albertus T.J., de Gorter, David J.J., Schuringa, Jan Jacob, van Bennekum, Ariëtte M., Drenth-Diephuis, Loes, Vellenga, Edo, Eggen, Bart J.L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Cell Biology 2005
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1182292/
https://ncbi.nlm.nih.gov/pubmed/15917296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E04-11-1033
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