Functional Analysis of Genetic Variation in Catechol-O-Methyltransferase (COMT): Effects on mRNA, Protein, and Enzyme Activity in Postmortem Human Brain

Catechol-O-methyltransferase (COMT) is a key enzyme in the elimination of dopamine in the prefrontal cortex of the human brain. Genetic variation in the COMT gene (MIM 116790) has been associated with altered prefrontal cortex function and higher risk for schizophrenia, but the specific alleles and...

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Bibliografische gegevens
Hoofdauteurs: Chen, Jingshan, Lipska, Barbara K., Halim, Nader, Ma, Quang D., Matsumoto, Mitsuyuki, Melhem, Samer, Kolachana, Bhaskar S., Hyde, Thomas M., Herman, Mary M., Apud, Jose, Egan, Michael F., Kleinman, Joel E., Weinberger, Daniel R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The American Society of Human Genetics 2004
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1182110/
https://ncbi.nlm.nih.gov/pubmed/15457404
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