Immunogenicity of Heterologous Prime-Boost Regimens Involving Recombinant Adenovirus Serotype 11 (Ad11) and Ad35 Vaccine Vectors in the Presence of Anti-Ad5 Immunity

The high prevalence of preexisting immunity to adenovirus serotype 5 (Ad5) in human populations will likely limit the immunogenicity and clinical utility of recombinant Ad5 (rAd5) vector-based vaccines for human immunodeficiency virus type 1 and other pathogens. A potential solution to this problem...

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Autori principali: Lemckert, Angelique A. C., Sumida, Shawn M., Holterman, Lennart, Vogels, Ronald, Truitt, Diana M., Lynch, Diana M., Nanda, Anjali, Ewald, Bonnie A., Gorgone, Darci A., Lifton, Michelle A., Goudsmit, Jaap, Havenga, Menzo J. E., Barouch, Dan H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2005
Soggetti:
Pathogenesis and Immunity
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1181575/
https://ncbi.nlm.nih.gov/pubmed/16014931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.15.9694-9701.2005
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