Human Immunodeficiency Virus Reactivation by Phorbol Esters or T-Cell Receptor Ligation Requires both PKCα and PKCθ

Latently human immunodeficiency virus (HIV)-infected memory CD4(+) T cells represent the major obstacle to eradicating HIV from infected patients. Antigens, T-cell receptor (TCR) ligation, and phorbol esters can reactivate HIV from latency in a protein kinase C (PKC)-dependent manner; however, it is...

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Autors principals: Trushin, Sergey A., Bren, Gary D., Asin, Susana, Pennington, Kevin N., Paya, Carlos V., Badley, Andrew D.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2005
Matèries:
Genome Replication and Regulation of Viral Gene Expression
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1181554/
https://ncbi.nlm.nih.gov/pubmed/16014943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.15.9821-9830.2005
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