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Two-Locus Heterogeneity Cannot Be Distinguished from Two-Locus Epistasis on the Basis of Affected-Sib-Pair Data

The observation of multiple linkage signals in the course of conducting genome screens for complex disorders raises the question of whether distinct genes represent independent causes of disease (heterogeneity) or whether they interact to produce the phenotype of interest (epistasis); and there has...

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Bibliografiska uppgifter
Huvudupphovsmän: Vieland, Veronica J., Huang, Jian
Materialtyp: Artigo
Språk:Inglês
Publicerad: The American Society of Human Genetics 2003
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1180363/
https://ncbi.nlm.nih.gov/pubmed/12830401
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