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Two-Locus Heterogeneity Cannot Be Distinguished from Two-Locus Epistasis on the Basis of Affected-Sib-Pair Data

The observation of multiple linkage signals in the course of conducting genome screens for complex disorders raises the question of whether distinct genes represent independent causes of disease (heterogeneity) or whether they interact to produce the phenotype of interest (epistasis); and there has...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Vieland, Veronica J., Huang, Jian
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society of Human Genetics 2003
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1180363/
https://ncbi.nlm.nih.gov/pubmed/12830401
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