Accumulation of Mitochondrial DNA Mutations in Human Immunodeficiency Virus–Infected Patients Treated with Nucleoside-Analogue Reverse-Transcriptase Inhibitors

Nucleoside reverse-transcriptase inhibitor (NRTI) therapy for human immunodeficiency virus (HIV) infection has been associated with mitochondrial DNA (mtDNA) polymerase-γ inhibition and subsequent mtDNA depletion. Effects on mtDNA mutation, although suggested by critical involvement of polymerase-γ...

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Main Authors: Martin, Annalise M., Hammond, Emma, Nolan, David, Pace, Craig, Den Boer, Marion, Taylor, Louise, Moore, Hannah, Martinez, Olga Patricia, Christiansen, Frank T., Mallal, Simon
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Human Genetics 2003
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1180231/
https://ncbi.nlm.nih.gov/pubmed/12587093
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