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Autoantigen, innate immunity, and T cells cooperate to break B cell tolerance during bacterial infection
Autoantibody production during infections is considered to result from nonspecific activation of low-affinity autoreactive B cells. Whether this can lead to autoimmune disease remains uncertain. We show that chronic infection by Borrelia burgdorferi of Tg animals expressing human rheumatoid factor (...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1177998/ https://ncbi.nlm.nih.gov/pubmed/16041408 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI24646 |
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