Autoantigen, innate immunity, and T cells cooperate to break B cell tolerance during bacterial infection

Autoantibody production during infections is considered to result from nonspecific activation of low-affinity autoreactive B cells. Whether this can lead to autoimmune disease remains uncertain. We show that chronic infection by Borrelia burgdorferi of Tg animals expressing human rheumatoid factor (...

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Bibliographic Details
Main Authors: Soulas, Pauline, Woods, Anne, Jaulhac, Benoit, Knapp, Anne-Marie, Pasquali, Jean-Louis, Martin, Thierry, Korganow, Anne-Sophie
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2005
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1177998/
https://ncbi.nlm.nih.gov/pubmed/16041408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI24646
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