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The proteasome inhibitor MG-132 sensitizes PC-3 prostate cancer cells to ionizing radiation by a DNA-PK-independent mechanism

BACKGROUND: By modulating the expression levels of specific signal transduction molecules, the 26S proteasome plays a central role in determining cell cycle progression or arrest and cell survival or death in response to stress stimuli, including ionizing radiation. Inhibition of proteasome function...

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Detalhes bibliográficos
Main Authors: Pajonk, Frank, van Ophoven, Arndt, Weissenberger, Christian, McBride, William H
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1177933/
https://ncbi.nlm.nih.gov/pubmed/16001975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-5-76
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