Prevalence of von Hippel-Lindau gene mutations in sporadic renal cell carcinoma: results from the Netherlands cohort study

BACKGROUND: Biallelic von Hippel-Lindau (VHL) gene defects, a rate-limiting event in the carcinogenesis, occur in approximately 75% of sporadic clear-cell Renal Cell Carcinoma (RCC). We studied the VHL mutation status in a large population-based case group. METHODS: Cases were identified within the...

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Main Authors: van Houwelingen, Kjeld P, van Dijk, Boukje AC, Hulsbergen-van de Kaa, Christina A, Schouten, Leo J, Gorissen, Hanneke JM, Schalken, Jack A, van den Brandt, Piet A, Oosterwijk, Egbert
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2005
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1177929/
https://ncbi.nlm.nih.gov/pubmed/15932632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-5-57
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