Germ-Line Mutations in the von Hippel–Lindau Tumor-Suppressor Gene Are Similar to Somatic von Hippel–Lindau Aberrations in Sporadic Renal Cell Carcinoma

von Hippel–Lindau (VHL) disease is a hereditary tumor syndrome predisposing to multifocal bilateral renal cell carcinomas (RCCs), pheochromocytomas, and pancreatic tumors, as well as angiomas and hemangioblastomas of the CNS. A candidate gene for VHL was recently identified, which led to the isolati...

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Autori principali: Whaley, Jean M., Naglich, Joseph, Gelbert, Lawrence, Hsia, Y. Edward, Lamiell, James M., Green, Jane S., Collins, Debra, Neumann, Hartmut P. H., Laidlaw, Jana, Li, Fred P., Klein-Szanto, Andres J. P., Seizinger, Bernd R., Kley, Nikolai
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1994
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1918449/
https://ncbi.nlm.nih.gov/pubmed/7977367
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