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Transmembrane topogenesis of a tail-anchored protein is modulated by membrane lipid composition

A large class of proteins with cytosolic functional domains is anchored to selected intracellular membranes by a single hydrophobic segment close to the C-terminus. Although such tail-anchored (TA) proteins are numerous, diverse, and functionally important, the mechanism of their transmembrane inser...

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Bibliographische Detailangaben
Hauptverfasser: Brambillasca, Silvia, Yabal, Monica, Soffientini, Paolo, Stefanovic, Sandra, Makarow, Marja, Hegde, Ramanujan S, Borgese, Nica
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2005
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1176458/
https://ncbi.nlm.nih.gov/pubmed/15973434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600730
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