Preclinical Assessment of HIV Vaccines and Microbicides by Repeated Low-Dose Virus Challenges

BACKGROUND: Trials in macaque models play an essential role in the evaluation of biomedical interventions that aim to prevent HIV infection, such as vaccines, microbicides, and systemic chemoprophylaxis. These trials are usually conducted with very high virus challenge doses that result in infection...

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Bibliographic Details
Main Authors: Regoes, Roland R, Longini, Ira M, Feinberg, Mark B, Staprans, Silvija I
Format: Artigo
Language:Inglês
Published: Public Library of Science 2005
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1176242/
https://ncbi.nlm.nih.gov/pubmed/16018721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.0020249
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