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Down-Regulation of Protease-activated Receptor-1 Is Regulated by Sorting Nexin 1

Degradation or “down-regulation” of protease-activated receptor-1 (PAR1), a G protein-coupled receptor for thrombin, is critical for termination of receptor signaling. Toward understanding the molecular mechanisms by which activated PAR1 is internalized, sorted to lysosomes, and degraded, we investi...

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Bibliografiske detaljer
Udgivet i:Mol Biol Cell
Principais autores: Wang, Yingjie, Zhou, Yixing, Szabo, Katalin, Haft, Carol Renfrew, Trejo, JoAnn
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Cell Biology 2002
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC117618/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12058063/
https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.E01-11-0131
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