Tumor attenuation by combined heparan sulfate and polyamine depletion

Cells depend on polyamines for growth and their depletion represents a strategy for the treatment of cancer. Polyamines assemble de novo through a pathway sensitive to the inhibitor, α-difluoromethylornithine (DFMO). However, the presence of cell-surface heparan sulfate proteoglycans may provide a s...

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Autors principals: Belting, Mattias, Borsig, Lubor, Fuster, Mark M., Brown, Jillian R., Persson, Lo, Fransson, Lars-Åke, Esko, Jeffrey D.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2002
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC117567/
https://ncbi.nlm.nih.gov/pubmed/11752393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.012346499
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