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Tumor attenuation by combined heparan sulfate and polyamine depletion
Cells depend on polyamines for growth and their depletion represents a strategy for the treatment of cancer. Polyamines assemble de novo through a pathway sensitive to the inhibitor, α-difluoromethylornithine (DFMO). However, the presence of cell-surface heparan sulfate proteoglycans may provide a s...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The National Academy of Sciences
2002
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC117567/ https://ncbi.nlm.nih.gov/pubmed/11752393 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.012346499 |
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