Tumor attenuation by combined heparan sulfate and polyamine depletion

Cells depend on polyamines for growth and their depletion represents a strategy for the treatment of cancer. Polyamines assemble de novo through a pathway sensitive to the inhibitor, α-difluoromethylornithine (DFMO). However, the presence of cell-surface heparan sulfate proteoglycans may provide a s...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Belting, Mattias, Borsig, Lubor, Fuster, Mark M., Brown, Jillian R., Persson, Lo, Fransson, Lars-Åke, Esko, Jeffrey D.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2001
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC117567/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11752393/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.012346499
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