DNA sequence recognition in the minor groove by crosslinked polyamides: The effect of N-terminal head group and linker length on binding affinity and specificity

Development of sequence-reading polyamides or “lexitropsins” with comparable DNA-binding affinities to cellular proteins raises the possibility of artificially regulated gene expression. Covalent linkage of polyamide ligands, with either a hairpin motif or crosslinking methylene bridge, has greatly...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	O'Hare, C. Caroline, Mack, Darcy, Tandon, Manju, Sharma, Sanjay K., Lown, J. William, Kopka, Mary L., Dickerson, Richard E., Hartley, John A.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2001
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC117516/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11756678/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.012588799
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