DNA sequence recognition in the minor groove by crosslinked polyamides: The effect of N-terminal head group and linker length on binding affinity and specificity

Development of sequence-reading polyamides or “lexitropsins” with comparable DNA-binding affinities to cellular proteins raises the possibility of artificially regulated gene expression. Covalent linkage of polyamide ligands, with either a hairpin motif or crosslinking methylene bridge, has greatly...

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Bibliografiske detaljer
Main Authors: O'Hare, C. Caroline, Mack, Darcy, Tandon, Manju, Sharma, Sanjay K., Lown, J. William, Kopka, Mary L., Dickerson, Richard E., Hartley, John A.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC117516/
https://ncbi.nlm.nih.gov/pubmed/11756678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.012588799
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