Doxorubicin activates nuclear factor of activated T-lymphocytes and Fas ligand transcription: role of mitochondrial reactive oxygen species and calcium

Doxorubicin (DOX), a widely used antitumour drug, causes dose-dependent cardiotoxicity. Cardiac mitochondria represent a critical target organelle of toxicity during DOX chemotherapy. Proposed mechanisms include generation of ROS (reactive oxygen species) and disturbances in mitochondrial calcium ho...

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Detalhes bibliográficos
Main Authors: Kalivendi, Shasi V., Konorev, Eugene A., Cunningham, Sonya, Vanamala, Sravan K., Kaji, Eugene H., Joseph, Joy, Kalyanaraman, B.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2005
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1175131/
https://ncbi.nlm.nih.gov/pubmed/15799720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20050285
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