Increased level of phosphorylated akt measured by chemiluminescence-linked immunosorbent assay is a predictor of poor prognosis in primary breast cancer overexpressing ErbB-2

INTRODUCTION: Akt1, Akt2 and Akt3 kinases are downstream components of phosphoinositol 3-kinase derived signals from receptor tyrosine kinases, which influence cell growth, proliferation and survival. Akt2 overexpression and amplification have been described in breast, ovarian and pancreatic cancers...

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Detalhes bibliográficos
Main Authors: Cicenas, Jonas, Urban, Patrick, Vuaroqueaux, Vincent, Labuhn, Martin, Küng, Willy, Wight, Edward, Mayhew, Mark, Eppenberger, Urs, Eppenberger-Castori, Serenella
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2005
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1175052/
https://ncbi.nlm.nih.gov/pubmed/15987444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr1015
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