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Peroxynitrite generated by inducible nitric oxide synthase and NADPH oxidase mediates microglial toxicity to oligodendrocytes

Reactive microglia in the CNS have been implicated in the pathogenesis of white matter disorders, such as periventricular leukomalacia and multiple sclerosis. However, the mechanism by which activated microglia kill oligodendrocytes (OLs) remains elusive. Here we show that lipopolysaccharide (LPS)-i...

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Bibliographische Detailangaben
Hauptverfasser: Li, Jianrong, Baud, Olivier, Vartanian, Timothy, Volpe, Joseph J., Rosenberg, Paul A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2005
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1174990/
https://ncbi.nlm.nih.gov/pubmed/15998743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0502552102
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