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A peptide that binds and stabilizes p53 core domain: Chaperone strategy for rescue of oncogenic mutants
Conformationally compromised oncogenic mutants of the tumor suppressor protein p53 can, in principle, be rescued by small molecules that bind the native, but not the denatured state. We describe a strategy for the rational search for such molecules. A nine-residue peptide, CDB3, which was derived fr...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The National Academy of Sciences
2002
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC117409/ https://ncbi.nlm.nih.gov/pubmed/11782540 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.241629998 |
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