A peptide that binds and stabilizes p53 core domain: Chaperone strategy for rescue of oncogenic mutants

Conformationally compromised oncogenic mutants of the tumor suppressor protein p53 can, in principle, be rescued by small molecules that bind the native, but not the denatured state. We describe a strategy for the rational search for such molecules. A nine-residue peptide, CDB3, which was derived fr...

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Bibliografiske detaljer
Main Authors: Friedler, Assaf, Hansson, Lars O., Veprintsev, Dmitry B., Freund, Stefan M. V., Rippin, Thomas M., Nikolova, Penka V., Proctor, Mark R., Rüdiger, Stefan, Fersht, Alan R.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC117409/
https://ncbi.nlm.nih.gov/pubmed/11782540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.241629998
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