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Grafts of supplementary thymuses injected with allogeneic pancreatic islets protect nonobese diabetic mice against diabetes

In nonobese diabetic (NOD) mice, the autoimmune attack of the β-cells in pancreatic islets is now believed to result from abnormal thymic selection. Accordingly, grafts of thymic epithelium from NOD donors to athymic recipients promote autoimmune islet inflammation in normal strains, and intrathymic...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Salaün, J., Simmenauer, N., Belo, P., Coutinho, A., Le Douarin, N. M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC117398/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11792835/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.012597499
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