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Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α

To investigate whether the transcriptional activator hypoxia-inducible factor 1 (HIF-1) is required for ventilatory responses to hypoxia, we analyzed mice that were either wild type or heterozygous for a loss-of-function (knockout) allele at the Hif1a locus, which encodes the O(2)-regulated HIF-1α s...

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Hlavní autoři: Kline, David D., Peng, Ying-Jie, Manalo, Dominador J., Semenza, Gregg L., Prabhakar, Nanduri R.
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 2002
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC117389/
https://ncbi.nlm.nih.gov/pubmed/11792862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.022634199
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