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Abietadiene synthase catalysis: Mutational analysis of a prenyl diphosphate ionization-initiated cyclization and rearrangement

Abietadiene synthase catalyzes the committed step in resin acid biosynthesis, forming a mixture of abietadiene double-bond isomers by two sequential, mechanistically distinct cyclizations at separate active sites. The first reaction, protonation-initiated cyclization, converts the universal diterpen...

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Bibliografiske detaljer
Main Authors: Peters, Reuben J., Croteau, Rodney B.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2002
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC117348/
https://ncbi.nlm.nih.gov/pubmed/11805316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.022627099
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