Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure

Abnormalities in intracellular calcium release and reuptake are responsible for decreased contractility in heart failure (HF). We have previously shown that cardiac ryanodine receptors (RyRs) are protein kinase A-hyperphosphorylated and depleted of the regulatory subunit calstabin-2 in HF. Moreover,...

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Detalhes bibliográficos
Main Authors: Wehrens, Xander H. T., Lehnart, Stephan E., Reiken, Steven, van der Nagel, Roel, Morales, Raymond, Sun, Jie, Cheng, Zhenzhuang, Deng, Shi-Xiang, de Windt, Leon J., Landry, Donald W., Marks, Andrew R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1172237/
https://ncbi.nlm.nih.gov/pubmed/15972811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0500353102
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