The Escherichia coli trmE (mnmE) gene, involved in tRNA modification, codes for an evolutionarily conserved GTPase with unusual biochemical properties.

The evolutionarily conserved 50K protein of Escherichia coli, encoded by o454, contains a consensus GTP-binding motif. Here we show that 50K is a GTPase that differs extensively from regulatory GTPases such as p21. Thus, 50K exhibits a very high intrinsic GTPase hydrolysis rate, rather low affinity...

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Bibliographic Details
Main Authors: Cabedo, H, Macián, F, Villarroya, M, Escudero, J C, Martínez-Vicente, M, Knecht, E, Armengod, M E
Format: Artigo
Language:Inglês
Published: 1999
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171769/
https://ncbi.nlm.nih.gov/pubmed/10601028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.24.7063
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