Evolutionarily conserved proteins MnmE and GidA catalyze the formation of two methyluridine derivatives at tRNA wobble positions

The wobble uridine of certain bacterial and mitochondrial tRNAs is modified, at position 5, through an unknown reaction pathway that utilizes the evolutionarily conserved MnmE and GidA proteins. The resulting modification (a methyluridine derivative) plays a critical role in decoding NNG/A codons an...

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Hlavní autoři: Moukadiri, Ismaïl, Prado, Silvia, Piera, Julio, Velázquez-Campoy, Adrián, Björk, Glenn R., Armengod, M.-Eugenia
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2009
Témata:
Nucleic Acid Enzymes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790889/
https://ncbi.nlm.nih.gov/pubmed/19767610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp762
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