Evolutionarily conserved proteins MnmE and GidA catalyze the formation of two methyluridine derivatives at tRNA wobble positions

The wobble uridine of certain bacterial and mitochondrial tRNAs is modified, at position 5, through an unknown reaction pathway that utilizes the evolutionarily conserved MnmE and GidA proteins. The resulting modification (a methyluridine derivative) plays a critical role in decoding NNG/A codons an...

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Bibliographic Details
Main Authors: Moukadiri, Ismaïl, Prado, Silvia, Piera, Julio, Velázquez-Campoy, Adrián, Björk, Glenn R., Armengod, M.-Eugenia
Format: Artigo
Language:Inglês
Published: Oxford University Press 2009
Subjects:
Nucleic Acid Enzymes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790889/
https://ncbi.nlm.nih.gov/pubmed/19767610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp762
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