Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation.

Components of the ras signaling pathway contribute to activation of cellular p53. In MCF-7 cells, p38 kinase activated p53 more effectively than other members of the ras pathway. p53 and p38 kinase exist in the same physical complex, and co-expression of p38 stabilized p53 protein. In vitro, p38 kin...

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Autores principales: Bulavin, D V, Saito, S, Hollander, M C, Sakaguchi, K, Anderson, C W, Appella, E, Fornace, A J
Formato: Artigo
Lenguaje:Inglês
Publicado: 1999
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171747/
https://ncbi.nlm.nih.gov/pubmed/10581258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.23.6845
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