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Inducible nitric oxide synthase: role of the N-terminal beta-hairpin hook and pterin-binding segment in dimerization and tetrahydrobiopterin interaction.

The oxygenase domain of the inducible nitric oxide synthase (iNOSox; residues 1-498) is a dimer that binds heme, L-arginine and tetrahydrobiopterin (H(4)B) and is the site for nitric oxide synthesis. We examined an N-terminal segment that contains a beta-hairpin hook, a zinc ligation center and part...

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Detalhes bibliográficos
Main Authors: Ghosh, D K, Crane, B R, Ghosh, S, Wolan, D, Gachhui, R, Crooks, C, Presta, A, Tainer, J A, Getzoff, E D, Stuehr, D J
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171689/
https://ncbi.nlm.nih.gov/pubmed/10562538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.22.6260
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