Nitric-oxide Synthase Forms N-NO-pterin and S-NO-Cys: IMPLICATIONS FOR ACTIVITY, ALLOSTERY, AND REGULATION

Inducible nitric-oxide synthase (iNOS) produces biologically stressful levels of nitric oxide (NO) as a potent mediator of cellular cytotoxicity or signaling. Yet, how this nitrosative stress affects iNOS function in vivo is poorly understood. Here we define two specific non-heme iNOS nitrosation si...

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Detalhes bibliográficos
Main Authors: Rosenfeld, Robin J., Bonaventura, Joseph, Szymczyna, Blair R., MacCoss, Michael J., Arvai, Andrew S., Yates, John R., Tainer, John A., Getzoff, Elizabeth D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951232/
https://ncbi.nlm.nih.gov/pubmed/20659888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.072496
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