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Binding of the Shigella protein IpaA to vinculin induces F-actin depolymerization.
Shigella flexneri, the causative agent of bacillary dysentery, enters into epithelial cells by a macropinocytic process. IpaA, a Shigella protein secreted upon cell contact, binds to the focal adhesion protein vinculin and is required for efficient bacterial uptake. IpaA was shown here to bind with...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
1999
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1171651/ https://ncbi.nlm.nih.gov/pubmed/10545097 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.21.5853 |
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