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Binding of the Shigella protein IpaA to vinculin induces F-actin depolymerization.

Shigella flexneri, the causative agent of bacillary dysentery, enters into epithelial cells by a macropinocytic process. IpaA, a Shigella protein secreted upon cell contact, binds to the focal adhesion protein vinculin and is required for efficient bacterial uptake. IpaA was shown here to bind with...

詳細記述

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書誌詳細
主要な著者: Bourdet-Sicard, R, Rüdiger, M, Jockusch, B M, Gounon, P, Sansonetti, P J, Nhieu, G T
フォーマット: Artigo
言語:Inglês
出版事項: 1999
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171651/
https://ncbi.nlm.nih.gov/pubmed/10545097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.21.5853
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