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Increased apoptosis induction by 121F mutant p53.
p53 mutants in tumours have a reduced affinity for DNA and a reduced ability to induce apoptosis. We describe a mutant with the opposite phenotype, an increased affinity for some p53-binding sites and an increased ability to induce apoptosis. The apoptotic function requires transcription activation...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
1999
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1171517/ https://ncbi.nlm.nih.gov/pubmed/10449408 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.16.4424 |
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