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Binding of SeqA protein to DNA requires interaction between two or more complexes bound to separate hemimethylated GATC sequences.

The SeqA protein binds to the post-replicative forms of the origins of replication of the Escherichia coli chromosome (oriC) and the P1 plasmid (P1oriR) at hemimethylated GATC adenine methylation sites. It appears to regulate replication by preventing premature reinitiation. However, SeqA binding is...

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Bibliographic Details
Main Authors: Brendler, T, Austin, S
Format: Artigo
Language:Inglês
Published: 1999
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171313/
https://ncbi.nlm.nih.gov/pubmed/10205183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.8.2304
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