Structural and biochemical analyses of hemimethylated DNA binding by the SeqA protein

The Escherichia coli SeqA protein recognizes the 11 hemimethylated G-(m)A-T-C sites in the oriC region of the chromosome, and prevents replication over-initiation within one cell cycle. The crystal structure of the SeqA C-terminal domain with hemimethylated DNA revealed the N(6)-methyladenine recogn...

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Udgivet i:Nucleic Acids Res
Main Authors: Fujikawa, Norie, Kurumizaka, Hitoshi, Nureki, Osamu, Tanaka, Yoshinori, Yamazoe, Mitsuyoshi, Hiraga, Sota, Yokoyama, Shigeyuki
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2004
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Articles
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC373283/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14704346/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkh173
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