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Leukemic transformation by the v-ErbA oncoprotein entails constitutive binding to and repression of an erythroid enhancer in vivo.

v-ErbA, a mutated thyroid hormone receptor alpha (TRalpha), is thought to contribute to avian erythroblastosis virus (AEV)-induced leukemic transformation by constitutively repressing transcription of target genes. However, the binding of v-ErbA or any unliganded nuclear receptor to a chromatin-embe...

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Detalhes bibliográficos
Main Authors: Ciana, P, Braliou, G G, Demay, F G, von Lindern, M, Barettino, D, Beug, H, Stunnenberg, H G
Formato: Artigo
Idioma:Inglês
Publicado em: 1998
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171083/
https://ncbi.nlm.nih.gov/pubmed/9857194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.24.7382
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