A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor.

The ectodomains of many proteins located at the cell surface are shed upon cell stimulation. One such protein is the heparin-binding EGF-like growth factor (HB-EGF) that exists in a membrane-anchored form which is converted to a soluble form upon cell stimulation with TPA, an activator of protein ki...

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Autors principals: Izumi, Y, Hirata, M, Hasuwa, H, Iwamoto, R, Umata, T, Miyado, K, Tamai, Y, Kurisaki, T, Sehara-Fujisawa, A, Ohno, S, Mekada, E
Format: Artigo
Idioma:Inglês
Publicat: 1998
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171072/
https://ncbi.nlm.nih.gov/pubmed/9857183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.24.7260
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