Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration.

The focal adhesion kinase (FAK) protein-tyrosine kinase (PTK) links transmembrane integrin receptors to intracellular signaling pathways. We show that expression of the FAK-related PTK, Pyk2, is elevated in fibroblasts isolated from murine fak-/- embryos (FAK-) compared with cells from fak+/+ embryo...

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Detalhes bibliográficos
Main Authors: Sieg, D J, Ilić, D, Jones, K C, Damsky, C H, Hunter, T, Schlaepfer, D D
Formato: Artigo
Idioma:Inglês
Publicado em: 1998
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170921/
https://ncbi.nlm.nih.gov/pubmed/9774338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.20.5933
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